ARHGEF11 Polyclonal Antibody

Background:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Research Area: Signal Transduction

Synonyms:
ARHGB, ARHGEF 11, ARHGEF11, DKFZp667F1223, Glutamate transporter EAAT4 associated protein 48, GTRAP 48, GTRAP48, KIAA0380, OTTHUMP00000038716, OTTHUMP00000038717, PDZ RHOGEF, PDZ-RhoGEF, Rho guanine exchange factor (GEF) 11, Rho guanine nucleotide exchange factor (GEF) 11, Rho guanine nucleotide exchange factor 11, RhoA specific guanine nucleotide exchange factor, RhoGEF glutamate transport modulator

Immunogen: Synthetic peptide of human ARHGEF11

Swissprot: O15085
Gene Accession: NP_055599

Calculated MW: 168 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-46233/sc-46232/sc-46234/sc-46235/sc-67023