ARHGEF12 Polyclonal Antibody

Background:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Signal transduction

Synonyms:
ARHGC, ARHGEF12, KIAA0382, leukemia-associated rho guanine nucleotide exchange factor, Leukemia-associated RhoGEF, PRO2792, Rho guanine exchange factor (GEF) 12, Rho guanine nucleotide exchange factor (GEF) 12, Rho guanine nucleotide exchange factor 12, Similar to Mouse Lsc oncogene

Immunogen: Synthetic peptide of human ARHGEF12

Swissprot: Q9NZN5
Gene Accession: NP_056128

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-15439/sc-15440/sc-25638