ARHGEF6 Polyclonal Antibody

Background:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

Research Area: Signal Transduction

Synonyms:
Alpha Pix, Alpha-Pix, ARHG6, ARHGEF6, COOL 2, COOL-2, COOL2, Mental retardation, X linked 46, MRX46, PAK interacting exchange factor alpha, PAK-interacting exchange factor alpha, PIXA, Rac/Cdc42 guanine exchange factor (GEF) 6, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6, Rac/Cdc42 guanine nucleotide exchange factor 6, Rho guanine nucleotide exchange factor 6

Immunogen: Synthetic peptide of human ARHGEF6

Swissprot: Q15052
Gene Accession: NP_004831

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-10925/sc-10927