ARHGEF7 Polyclonal Antibody

Background:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Signal Transduction

Synonyms:
ARHG7, ARHG7, ARHGEF 7, Arhgef7, Beta pix, Beta-Pix, betaPix, betaPix-b, betaPix-c, Cool, COOL-1, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, KIAA0412, mKIAA0142, Nbla10314, P50, P50BP, p85, P85COOL1, P85SPR, PAK interacting exchange factor beta, PAK-interacting exchange factor beta, PAK3, Pak3bp, PIX, PIXB, Rho guanine nucleotide exchange factor (GEF) 7, Rho guanine nucleotide exchange factor (GEF) 7b, Rho guanine nucleotide exchange factor (GEF7), Rho guanine nucleotide exchange factor 7, SH3 domain containing proline rich protein

Immunogen: Recombinant protein of human ARHGEF7

Swissprot: Q14155
Gene Accession: BC060776

Calculated MW: 90 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-10932/sc-10931/sc-25418