Arkadia Polyclonal Antibody

Background:
ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Alternative Names:
RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111

Immunogen: The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 110

GeneID: RNF111

Storage: -20°C/1 year

NOTE: For Research Use Only