ARNT Antibody (Center V528) Blocking Peptide
€363.00
In stock
SKU
AC-BP14310c
Background:
The aryl hydrocarbon (Ah) receptor is involved in theinduction of several enzymes that participate in xenobioticmetabolism. The ligand-free, cytosolic form of the Ah receptor iscomplexed to heat shock protein 90. Binding of ligand, whichincludes dioxin and polycyclic aromatic hydrocarbons, results intranslocation of the ligand-binding subunit only to the nucleus.Induction of enzymes involved in xenobiotic metabolism occursthrough binding of the ligand-bound Ah receptor to xenobioticresponsive elements in the promoters of genes for these enzymes.This gene encodes a protein that forms a complex with theligand-bound Ah receptor, and is required for receptor function.The encoded protein has also been identified as the beta subunit ofa heterodimeric transcription factor, hypoxia-inducible factor 1. At(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusionprotein, is associated with acute myeloblastic leukemia.Alternative splicing results in multiple transcript variants.
Other Names:
Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2
Gene Name: ARNT (HGNC:700)
Gene ID: 405
Primary Accession: P27540
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The aryl hydrocarbon (Ah) receptor is involved in theinduction of several enzymes that participate in xenobioticmetabolism. The ligand-free, cytosolic form of the Ah receptor iscomplexed to heat shock protein 90. Binding of ligand, whichincludes dioxin and polycyclic aromatic hydrocarbons, results intranslocation of the ligand-binding subunit only to the nucleus.Induction of enzymes involved in xenobiotic metabolism occursthrough binding of the ligand-bound Ah receptor to xenobioticresponsive elements in the promoters of genes for these enzymes.This gene encodes a protein that forms a complex with theligand-bound Ah receptor, and is required for receptor function.The encoded protein has also been identified as the beta subunit ofa heterodimeric transcription factor, hypoxia-inducible factor 1. At(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusionprotein, is associated with acute myeloblastic leukemia.Alternative splicing results in multiple transcript variants.
Other Names:
Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2
Gene Name: ARNT (HGNC:700)
Gene ID: 405
Primary Accession: P27540
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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