Aromatase polyclonal, anti-human

Quantity: 100 µg

Background:
Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons. By in situ hybridization, the ARO gene is mapped to 15q21.1. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development. Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, which can cause gynecomastia.

Description:
Rabbit IgG polyclonal antibody for Cytochrome P450 19A1 (CYP19A1) detection. Tested with WB, IHC-P in Human.

Synonyms:
ARO 1 antibody, ARO antibody, ARO1 antibody, Aromatase antibody, CP19A_HUMAN antibody, CPV antibody, CPV1 antibody, CYAR antibody, CYP19 antibody, CYP19A1 antibody, CYPXIX antibody, Cytochrome P-450AROM antibody, Cytochrome P450 19A1 antibody, Cytochrome P450 family 19 subfamily A polypeptide 1 antibody, Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody, Cytochrome P450, subfamily XIX(aromatization of androgens) antibody, Estrogen synthase antibody, Estrogen synthetase antibody, Flavoprotein linked monooxygenase antibody, MGC104309 antibody, Microsomal monooxygenase antibody, OTTHUMP00000162543 antibody, OTTHUMP00000198350 antibody, P 450AROM antibody, P450AROM antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Aromatase(485-503aa KNMLEMIFTPRNSDRCLEH).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.