ARPP-21 rabbit polyclonal, anti-human, mouse

Backgroud: This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],function:Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.,PTM:Isoform 1 is methylated by CARM1 in immature thymocytes.,PTM:Phosphorylation at Ser-56 favors interaction with CALM1.,similarity:Contains 1 R3H domain.,subunit:Interacts with CALM1.,tissue specificity:Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).,

Synonyms: ARPP21, TARPP, cAMP-regulated phosphoprotein 21, ARPP-21, Thymocyte cAMP-regulated phosphoprotein

Gene Name: ARPP21

Gene ID: 10777

SwissProt ID: Q9UBL0

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.