ARRB1 (clone 4E11B1), anti-human

Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Research Area: Signal Transduction

Synonyms: ARB1, ARR1

Immunogen: Purified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Storage:
4°C|-20°C for long term storage