ARRB1 Polyclonal Antibody

Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
ARRB1, ARB1, ARR1

Immunogen: Recombinant fusion protein of human ARRB1 (NP_004032.2).

Swissprot: P49407
Gene ID: 408

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.