Arrestin β1 polyclonal, anti-human, mouse, rat

Background:
The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the β-Arrestin family regulate receptor binding to G proteins. β-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with βARK (βARK1, also designated GRK 2, or βARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of β-Arrestin-1 and b-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that β-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses.

Alternative Name:
ARRB1, ARR1, ARB1, ARR1, ARRB1, ARRB1, Arrestin 2, Arrestin beta 1, Arrestin beta-1, Beta-arrestin-1,

Application Dilution:
WB:1:500-1:1000
ICC:1:50-1:200
IHC:1:50-1:100
FC:1:50-1:100

Specificity: Arrestin β1 polyclonal antibody detects endogenous levels of Arrestin β1 protein.

Immunogen:
Peptide

MW: 50 kDa

Swiss-Prot: P49407(Human) Q8BWG8(Mouse) P29066(Rat)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.