Arrestin beta 2 polyclonal, anti-human, mouse, rat

Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Other Names:
Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2

Antigen Types:
Synthetic Peptide

Gene Name:
ARRB2
Gene ID:
409
Primary Accession: P32121
Other Accession: NP_945355;409;