ASAP2 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17248b
Background:
This gene encodes a multidomain protein containing anN-terminal alpha-helical region with a coiled-coil motif, followedby a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrinhomology region, a proline-rich region, and a C-terminal Srchomology 3 (SH3) domain. The protein localizes in the Golgiapparatus and at the plasma membrane, where it colocalizes withprotein tyrosine kinase 2-beta (PYK2). The encoded protein forms astable complex with PYK2 in vivo. This interaction appears to bemediated by binding of its SH3 domain to the C-terminalproline-rich domain of PYK2. The encoded protein is tyrosinephosphorylated by activated PYK2. It has catalytic activity forclass I and II ArfGAPs in vitro, and can bind the class III ArfARF6 without immediate GAP activity. The encoded protein isbelieved to function as an ARF GAP that controls ARF-mediatedvesicle budding when recruited to Golgi membranes. In addition, itfunctions as a substrate and downstream target for PYK2 and SRC, apathway that may be involved in the regulation of vesiculartransport. Multiple transcript variants encoding different isoformshave been found for this gene.
Other Names:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2, Development and differentiation-enhancing factor 2, Paxillin-associated protein with ARF GAP activity 3, PAG3, Pyk2 C-terminus-associated protein, PAP, ASAP2, DDEF2, KIAA0400
Gene Name: ASAP2
Gene ID: 8853
Primary Accession: O43150
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a multidomain protein containing anN-terminal alpha-helical region with a coiled-coil motif, followedby a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrinhomology region, a proline-rich region, and a C-terminal Srchomology 3 (SH3) domain. The protein localizes in the Golgiapparatus and at the plasma membrane, where it colocalizes withprotein tyrosine kinase 2-beta (PYK2). The encoded protein forms astable complex with PYK2 in vivo. This interaction appears to bemediated by binding of its SH3 domain to the C-terminalproline-rich domain of PYK2. The encoded protein is tyrosinephosphorylated by activated PYK2. It has catalytic activity forclass I and II ArfGAPs in vitro, and can bind the class III ArfARF6 without immediate GAP activity. The encoded protein isbelieved to function as an ARF GAP that controls ARF-mediatedvesicle budding when recruited to Golgi membranes. In addition, itfunctions as a substrate and downstream target for PYK2 and SRC, apathway that may be involved in the regulation of vesiculartransport. Multiple transcript variants encoding different isoformshave been found for this gene.
Other Names:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2, Development and differentiation-enhancing factor 2, Paxillin-associated protein with ARF GAP activity 3, PAG3, Pyk2 C-terminus-associated protein, PAP, ASAP2, DDEF2, KIAA0400
Gene Name: ASAP2
Gene ID: 8853
Primary Accession: O43150
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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