ASCC1 Polyclonal Antibody

Background:
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Research Area: Signal Transduction

Synonyms:
Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, ASC1 complex subunit p50, ASC1p50, ASCC1, ASCC1, CGI 18, RP11-150D20.4, Trip4 complex subunit p50

Immunogen: Recombinant protein of human ASCC1

Swissprot: Q8N9N2
Gene Accession: BC012291

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-160156