ASCC1 Polyclonal Antibody

Background:
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Research Area: Signaling transduction

Synonyms:
ASCC1, ASC1p50, CGI-18, SMABF2, p50

Immunogen: Recombinant fusion protein of human ASCC1 (NP_001185727.1).

Swissprot: Q8N9N2
Gene ID: 51008

Calculated MW: 41 kDa/45 kDa
Observed MW: 46 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.