ASH2L Polyclonal Antibody

Background:
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
ASH 2, Ash2 (absent small or homeotic) like, Ash2 (absent, small, or homeotic) like (Drosophila), ASH2, ASH2 LIKE, ASH2 like protein, ASH2-like protein, Ash2l, ASH2L, ASH2L1>, ASH2L2, Bre 2, Bre2, Discs 2-like, Drosophila absent, small, or homeotic, Drosophila ASH2-like, Set1/Ash2 histone methyltransferase complex subunit ASH2

Immunogen: Recombinant protein of human ASH2L

Swissprot: Q9UBL3
Gene Accession: BC015936

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-27283