ASIC3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ASIC3(Acid-Sensing Ion Channel3), also known as TESTIS SODIUM CHANNEL 1(TNAC1) or DORSAL ROOT ACID-SENSING ION CHANNEL(DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the ACCN3 gene to chromosome 7q35. De Weille et al.(1998) found that human ASIC3 supported an H(+)-gated cation current in COS cells with kinetics similar to those of rat Asic3. Babinski et al.(1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH.

Description:
Rabbit IgG polyclonal antibody for Acid-sensing ion channel 3 (ASIC3) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
ACCN 3 antibody, ACCN3 antibody, ACCN3_HUMAN antibody, Acid sensing ion channel 3 antibody, Acid-sensing ion channel 3 antibody, Amiloride sensitive cation channel 3 antibody, Amiloride sensitive cation channel 3 testis antibody, Amiloride-sensitive cation channel 3 antibody, ASIC 3 antibody, ASIC3 antibody, DRASIC antibody, hASIC 3 antibody, hASIC3 antibody, hTNaC 1 antibody, hTNaC1 antibody, Modulatory subunit of ASIC 2a antibody, Modulatory subunit of ASIC2a antibody, Neuronal amiloride sensitive cation channel 3 antibody, Neuronal amiloride-sensitive cation channel 3 antibody, Proton gated cation channel subunit antibody, SLNAC 1 antibody, SLNAC1 antibody, Testis sodium channel 1 antibody, TNaC 1 antibody, TNaC1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human ASIC3(56-73aa FLYQVAERVRYYREFHHQ), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.