ASIC3 Polyclonal Antibody

Background:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described.

Research Area: Neuroscience

Synonyms:
ACCN 3, Accn3, ACCN3, Acid sensing ion channel 3, Acid-sensing ion channel 3, Amiloride sensitive cation channel 3, Amiloride sensitive cation channel 3 testis, Amiloride-sensitive cation channel 3, ASIC 3, ASIC3, DRASIC, hASIC 3, hASIC3, hTNaC 1, hTNaC1, Modulatory subunit of ASIC 2a, Modulatory subunit of ASIC2a, Neuronal amiloride sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Proton gated cation channel subunit, SLNAC 1, SLNAC1, Testis sodium channel 1, TNaC 1, TNaC1

Immunogen: Synthetic peptide of human ASIC3

Swissprot: Q9UHC3
Gene Accession: NP004760

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:2000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.