ASIP polyclonal, anti-human, mouse

Background:
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.

Synonyms: AGSW, AGTI, AGTIL, ASP, SHEP9

Cellular Location: Secreted

Immunogen:
Recombinant protein of human ASIP

Gene Symbol: ASIP

Gene ID: 434

Swiss prot: P42127

Calculated MW: 15kDa

Recommended dilution:
IHC 1:50-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.