ASK1/MAPKKK5 polyclonal, anti-human antibody
€295.00
In stock
SKU
AC-ABV10101-100
Catalog Number: AC-ABV10101-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IF
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IF
Datasheet
Request Information
Background:
ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas thro µgh the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-α induced apoptosis.
Other Names:
MAP3K5, MEKK5, ASK-1 , MAPKKK5
Primary Accession: Q99683
Gene Name: MAP3K5
Gene ID: 4217
Concentration (mg/ml): 0.2 mg/ml
ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas thro µgh the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-α induced apoptosis.
Other Names:
MAP3K5, MEKK5, ASK-1 , MAPKKK5
Primary Accession: Q99683
Gene Name: MAP3K5
Gene ID: 4217
Concentration (mg/ml): 0.2 mg/ml
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