ASK1 (MEKK5/MAP3K5) Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP7911a
Background:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that an MEKK5 transcript is abundantly expressed in human heart and pancreas. The MEKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MEKK5 does not activate MAPK/ERK. Check the site for more info: http://biocarta.com/pathfiles/h_mapkPathway.asp
Other Names:
Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7911a was selected from the C-term region of human MEKK5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAP3K5
Gene ID: 4217
Primary Accession: Q99683
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that an MEKK5 transcript is abundantly expressed in human heart and pancreas. The MEKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MEKK5 does not activate MAPK/ERK. Check the site for more info: http://biocarta.com/pathfiles/h_mapkPathway.asp
Other Names:
Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7911a was selected from the C-term region of human MEKK5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAP3K5
Gene ID: 4217
Primary Accession: Q99683
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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