Ataxin 3 Polyclonal Antibody

Background:
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
ATXN3, AT3, ATX3, JOS, MJD, MJD1, SCA3, ataxin-3, Ataxin 3

Immunogen: Recombinant fusion protein of human Ataxin 3 (NP_004984.2).

Swissprot: P54252
Gene ID: 4287

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.