Ataxin3 (MJD) polyclonal (N-term), anti-human
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In stock
SKU
AC-AP2181a
Catalog Number: AC-AP2181a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4606
Applications: IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4606
Applications: IHC-P
Datasheet
Request Information
Background:
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
Other Names:
Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3
Target/Specificity:
This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD).
Antigen Region:
29-59
Antigen Type: Synthetic Peptide
Gene Name: ATXN3 {ECO:0000303|PubMed:33157014, ECO:0000312|HGNC:HGNC:7106}
Gene ID: 4287
Primary Accession: P54252
NCBI Accession: NP_001121168.1;NP_001158252.1;NP_004984.2;NP_109376.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
Other Names:
Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3
Target/Specificity:
This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD).
Antigen Region:
29-59
Antigen Type: Synthetic Peptide
Gene Name: ATXN3 {ECO:0000303|PubMed:33157014, ECO:0000312|HGNC:HGNC:7106}
Gene ID: 4287
Primary Accession: P54252
NCBI Accession: NP_001121168.1;NP_001158252.1;NP_004984.2;NP_109376.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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