ATF3 antibody (clone 8G5), anti-human
€435.00
In stock
SKU
AC-AT1223a
Catalog Number: AC-AT1223a
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, E
Request Information AC-AT1223a">Request Information
Background:
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Other Names:
Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3
Antigen Type:
Recombinant Protein
Gene Name: ATF3 {ECO:0000303|PubMed:7515060, ECO:0000312|HGNC:HGNC:785}
Gene ID: 467
NCBI Accession: NP_001025458.1;NP_001035709.1;NP_001193413.2;NP_001193415.1;NP_001193417.2;NP_001665.1
Primary Accession: P18847
Other Accession: BC006322
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Other Names:
Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3
Antigen Type:
Recombinant Protein
Gene Name: ATF3 {ECO:0000303|PubMed:7515060, ECO:0000312|HGNC:HGNC:785}
Gene ID: 467
NCBI Accession: NP_001025458.1;NP_001035709.1;NP_001193413.2;NP_001193415.1;NP_001193417.2;NP_001665.1
Primary Accession: P18847
Other Accession: BC006322
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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