ATF7 polyclonal, anti-human, mouse, rat

Background:
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Alternative Name:
cAMP-dependent transcription factor ATF-7, ATF7, 1110012F10Rik, 9430065F09Rik, Activating transcription factor 7, AI549878, ATF7, Atf7 protein, ATF7, ATFA, C130020M04Rik, cAMP-dependent transcription factor ATF-7, Cyclic AMP-dependent transcription factor ATF 7, Cyclic AMP-dependent transcription factor ATF-7, MGC31554, MGC57182, Transcription factor ATF A, Transcription factor ATF-A,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ATF7 polyclonal antibody detects endogenous levels of ATF7 protein.

Immunogen:
recombinant protein

MW: 53 kDa

Swiss-Prot: P17544(Human) Q8R0S1(Mouse) Unigene:219706(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.