ATG4A monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8455b
Catalog Number: AC-AM8455b
Size: 80 µl, 400 µl
Isotype: mouse IgG2b,k
Clone Name: 1458CT808.66.25.69
Applications: WB, FC, IHC-P, IF
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG2b,k
Clone Name: 1458CT808.66.25.69
Applications: WB, FC, IHC-P, IF
Datasheet
Request Information
Background:
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Other Names:
Cysteine protease ATG4A, 3422-, AUT-like 2 cysteine endopeptidase, Autophagin-2, Autophagy-related cysteine endopeptidase 2, Autophagy-related protein 4 homolog A, hAPG4A, ATG4A, APG4A, AUTL2
Target/Specificity:
This ATG4A antibody is generated from a mouse immunized with a recombinant protein.
Gene Name: ATG4A {ECO:0000303|Ref.20, ECO:0000312|HGNC:HGNC:16489}
Gene ID: 115201
Primary Accession: Q8WYN0
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Other Names:
Cysteine protease ATG4A, 3422-, AUT-like 2 cysteine endopeptidase, Autophagin-2, Autophagy-related cysteine endopeptidase 2, Autophagy-related protein 4 homolog A, hAPG4A, ATG4A, APG4A, AUTL2
Target/Specificity:
This ATG4A antibody is generated from a mouse immunized with a recombinant protein.
Gene Name: ATG4A {ECO:0000303|Ref.20, ECO:0000312|HGNC:HGNC:16489}
Gene ID: 115201
Primary Accession: Q8WYN0
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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