ATG4B Blocking Peptide (Center)

Background:
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Other Names:
Cysteine protease ATG4B, 3422-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943

Target/Specificity:
The synthetic peptide sequence is selected from aa 260-290 of Human ATG4B

Gene Name: ATG4B {ECO:0000303|PubMed:15187094, ECO:0000312|HGNC:HGNC:20790}

Gene ID: 23192
Primary Accession: Q9Y4P1
Other Accession: Q8BGE6; Q6DG88; Q6PZ02; Q6PZ03
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.