ATG4B polyclonal, anti-human
€0.00
In stock
SKU
AC-AP1809d
Catalog Number: AC-AP1809d
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11843
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11843
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4, a cysteine protease required for autophagy, cleaves the C-terminal part of MAP1LC3 to form the activated molecule LC3-I. LC3-I is subsequently conjugated with phosphatidylethanolamine at the C-terminal glycine to form LC3-II, a marker for autophagy via its capacity to bind to autophagosomes.
Other Names:
Cysteine protease ATG4B, 3422-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943
Target/Specificity:
This ATG4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-284 amino acids from human ATG4B.
Antigen Region:
258-284
Antigen Type: Synthetic Peptide
Gene Name: ATG4B {ECO:0000303|PubMed:15187094, ECO:0000312|HGNC:HGNC:20790}
Gene ID: 23192
Primary Accession: Q9Y4P1
NCBI Accession: NP_037457.3;NP_847896.1
Other Accession: Q8BGE6; Q6DG88; Q6PZ02; Q6PZ03; A0A0G2QC33
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4, a cysteine protease required for autophagy, cleaves the C-terminal part of MAP1LC3 to form the activated molecule LC3-I. LC3-I is subsequently conjugated with phosphatidylethanolamine at the C-terminal glycine to form LC3-II, a marker for autophagy via its capacity to bind to autophagosomes.
Other Names:
Cysteine protease ATG4B, 3422-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943
Target/Specificity:
This ATG4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-284 amino acids from human ATG4B.
Antigen Region:
258-284
Antigen Type: Synthetic Peptide
Gene Name: ATG4B {ECO:0000303|PubMed:15187094, ECO:0000312|HGNC:HGNC:20790}
Gene ID: 23192
Primary Accession: Q9Y4P1
NCBI Accession: NP_037457.3;NP_847896.1
Other Accession: Q8BGE6; Q6DG88; Q6PZ02; Q6PZ03; A0A0G2QC33
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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