Atg4C monoclonal, anti-human

Description: Anti-Atg4C Rabbit Monoclonal Antibody . Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human.

Protein Function:
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms..

Other Names: Cysteine protease ATG4C, 3.4.22.-, AUT-like 3 cysteine endopeptidase, Autophagy-related cysteine endopeptidase 3, Autophagin-3, Autophagy-related protein 4 homolog C, HsAPG4C, ATG4C {ECO:0000303|PubMed:21177865, ECO:0000312|HGNC:HGNC:16040}

Clone Name(s):
Clone: ABIC-1

Subcellular Localization: Cytoplasm.

Tissue Specificity: Highly expressed in skeletal muscle, heart, liver and testis..

Gene ID: 84938

Immunogen: A synthesized peptide derived from human Atg4C

Calculated MW: 52497

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.