ATG9A polyclonal, anti-human, mouse, rat

Background:
Autophagy, a process that results in the lysosomal-dependent degradation of cytosolic compartments, is carried out by the autophagosome, which is a double-membrane vesicle whose formation is catalyzed by several autophagy-related gene (Atg) proteins. Atg9a (autophagy-related protein 9A), also known as APG9-like 1, is a 839 amino acid, multi-pass membrane protein that localizes to the pre-autophagosomal structure (PAS). Isolation membranes are suggested to originate from the PAS, enwrapping cytoplasmic components to form a double membrane autophagosome, which then fuses with the vacuole. Ubiquitously expressed in human adult tissues, Atg9a cycles between the Golgi and endosomes and, with the autophagosome-specific marker LC3, plays a critical role in starvation-induced autophagosome formation. Three isoforms of Atg9a exist as a result of alternative splicing events.

Alternative Name:
ATG9A, APG9 autophagy 9-like 1, APG9 like 1, APG9-like 1, APG9L1, ATG9, ATG9 autophagy related 9 homolog A, ATG9 autophagy related 9 homolog A (S. cerevisiae), ATG9A, ATG9A, Autophagy 9-like 1 protein, Autophagy related protein 9A, Autophagy-related protein 9A, mATG9, MGD3208, OTTHUMP00000206046, OTTHUMP00000206048, OTTHUMP00000206049, OTTHUMP00000206062,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: ATG9A polyclonal antibody detects endogenous levels of ATG9A protein.

Immunogen:
recombinant protein

MW: 94 kDa

Swiss-Prot: Q7Z3C6(Human) Q68FE2(Mouse) Q5FWU3(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.