ATIC (clone 3H12-C9-H9), anti-human, mouse, rat

Background:
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Synonyms: AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH

Cellular Location: Cytosol Plasma Membrane

Immunogen:
Purified recombinant human ATIC protein fragments expressed in E.coli.

Gene Symbol: ATIC

Gene ID: 471

Swiss prot: P31939

Calculated MW: 64kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.