ATM polyclonal, anti-human

Background:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1

Cellular Location: Nucleus Cytoplasm

Immunogen:
A synthetic peptide of human ATM

Gene Symbol: ATM

Gene ID: 472

Swiss prot: Q13315

Calculated MW: 350 kDa

Recommended dilution:
IHC 1:40-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.