ATP-Citrate Lyase (C-term (clone 3D9-E9-H8), anti-human, mouse, monkey

Background:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Synonyms: ACL, ATPCL, CLATP

Cellular Location: Cytoplasm

Immunogen:
Purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.

Gene Symbol: ATP-Citrate Lyase(C-term)

Gene ID: 47

Swiss prot: P53396

Calculated MW: 120kDa

Recommended dilution:
WB 1:1000, IHC 1:150

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.