ATP2A2 polyclonal, anti-human, mouse, rat

Background:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms: ATP2B, DAR, DD, SERCA2

Cellular Location: Endoplasmic reticulum membrane Multi-pass membrane protein Sarcoplasmic reticulum membrane

Immunogen:
Recombinant protein of human ATP2A2

Gene Symbol: ATP2A2

Gene ID: 488

Swiss prot: P16615

Calculated MW: 115kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:10-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.