ATP2B1 antibody (clone 300), anti-human
€435.00
In stock
SKU
AC-AT1235a
Catalog Number: AC-AT1235a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT1235a">Request Information
Background:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Plasma membrane calcium-transporting ATPase 1, PMCA1, Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1, ATP2B1, PMCA1
Antigen Type:
Recombinant Protein
Gene Name: ATP2B1 (HGNC:814)
Gene ID: 490
NCBI Accession: NP_001001323.1;NP_001673.2
Primary Accession: P20020
Other Accession: NM_001682
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Plasma membrane calcium-transporting ATPase 1, PMCA1, Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1, ATP2B1, PMCA1
Antigen Type:
Recombinant Protein
Gene Name: ATP2B1 (HGNC:814)
Gene ID: 490
NCBI Accession: NP_001001323.1;NP_001673.2
Primary Accession: P20020
Other Accession: NM_001682
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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