ATP7b polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ATPase, Cu++ transporting, beta polypeptide(Wilson disease) protein, also called ATP7B, is an ATPase that transports copper. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two putative copper-binding sites. ATP7B is mapped to 13q14.3. This protein functions as a monomer, exporting copper out of the cells. When copper levels are in excess, ATP7B redistributes to a vesicular compartment near the biliary canalicular membranes for elimination of excess copper into bile, and it is transported along liver cell microtubules via interaction with the p62 dynactin subunit.

Description:
Rabbit IgG polyclonal antibody for Copper-transporting ATPase 2 (ATP7B) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ATP7B antibody, ATPase Cu++ transporting beta polypeptide antibody, ATPase Cu++ transporting beta polypeptide antibody, ATPase, Cu(2+) transporting, beta polypeptide antibody, ATPase, Cu++ transporting, beta polypeptide antibody, Copper pump 2 antibody, Copper transporting ATPase 2 antibody, PWD antibody, Toxic milk antibody, tx antibody, WC1 antibody, WD antibody, Wilson disease associated protein antibody, Wilson disease-associated protein antibody, WND antibody, WND/140 kDa antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human ATP7b(1451-1465aa DKWSLLLNGRDEEQYI), different from the related mouse and rat sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.