ATR polyclonal, anti-human, mouse antibody
€295.00
In stock
SKU
AC-ABV10586-100
Catalog Number: AC-ABV10586-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
Other Names:
ATR, Ataxia telangiectasia and Rad3 related, FRAP, FRP1, FRAP-related protein 1, SCKL, SCKL1, Seckel syndrome
Primary Accession: Q13535
Gene Name: ATR
Gene ID: 545
ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
Other Names:
ATR, Ataxia telangiectasia and Rad3 related, FRAP, FRP1, FRAP-related protein 1, SCKL, SCKL1, Seckel syndrome
Primary Accession: Q13535
Gene Name: ATR
Gene ID: 545
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