ATR Polyclonal Antibody

Background:
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Ataxia telangiectasia and Rad3 related, Ataxia telangiectasia and Rad3-related protein, ATR, ATR, FCTCS, FRAP Related Protein 1, FRAP-related protein 1, FRP1, MEC1, MEC1 mitosis entry checkpoint 1 homolog, Protein kinase ATR, RAC3, Rad3 related protein, SCKL, SCKL1, Serine/threonine protein kinase ATR, Serine/threonine-protein kinase ATR

Immunogen: Synthetic peptide of human ATR

Swissprot: Q13535
Gene Accession: NP001175

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.1 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.