ATXN1 polyclonal (S776), anti-human
€0.00
In stock
SKU
AC-AP2808A
Catalog Number: AC-AP2808A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB16258
Applications: WB, IF
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB16258
Applications: WB, IF
Datasheet
Request Information
Background:
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
Other Names:
Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity:
This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Antigen Region:
754-781
Antigen Type: Synthetic Peptide
Gene Name: ATXN1
Gene ID: 6310
Primary Accession: P54253
NCBI Accession: NP_000323.2;NP_001121636.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
Other Names:
Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity:
This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Antigen Region:
754-781
Antigen Type: Synthetic Peptide
Gene Name: ATXN1
Gene ID: 6310
Primary Accession: P54253
NCBI Accession: NP_000323.2;NP_001121636.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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