ATXN3 Polyclonal Antibody

Background:
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
AT3, Ataxin 3, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant ref, Ataxin-3, ATX3, EC 3.4.22, JOS, Machado Joseph disease, MJD, Olivopontocerebellar ataxia 3, OTTHUMP00000221583, Rsca3, Spinocerebellar ataxia type 3 protein

Immunogen: Recombinant Human Ataxin-3 protien

Swissprot: P54252

Calculated MW: 41 kDa
Observed MW: 41 kDa,22 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.