ATXN3 Polyclonal Antibody

Background:
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
AT3, Ataxin 3, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant ref, Ataxin-3, ATX3, ATX3, ATXN3, EC 3.4.22., JOS, Josephin, Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3), Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD, MJD gene, MJD1, Olivopontocerebellar ataxia 3, OTTHUMP00000221583, OTTHUMP00000221585, OTTHUMP00000221586, OTTHUMP00000221587, OTTHUMP00000231995, OTTHUMP00000231997, Rsca3, SCA3, SCA3 gene, Spinocerebellar ataxia type 3 protein

Immunogen: Fusion protein of human ATXN3

Swissprot: P54252
Gene Accession: BC033711

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.