ATXN7L3 Polyclonal Antibody

Background:
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.

Research Area: Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
AT7L3, Ataxin 7 like 3, Ataxin 7 like protein 3, Ataxin-7-like protein 3, atxn7l3, SAGA associated factor 11 homolog, SAGA-associated factor 11 homolog

Immunogen: Fusion protein of human ATXN7L3

Swissprot: Q14CW9
Gene Accession: BC113595

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.