AUH Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP10124b
Background:
The methylglutaconyl-CoA hydratase, mitochondrial proteinbinds to the AU-rich element (ARE), a common element found in the3' UTR of rapidly decaying mRNA such as c-fos, c-myc andgranulocyte/ macrophage colony stimulating factor. ARE elements areinvolved in directing RNA to rapid degradation and deadenylation.AUH is also homologous to enol-CoA hydratase, an enzyme involved infatty acid degradation, and has been shown to have intrinsichydratase enzymatic activity. AUH is thus a bifunctional chimerabetween RNA binding and metabolic enzyme activity. A possiblesubcellular localization in the mitochondria has been demonstratedfor the mouse homolog of this protein which shares 92% identitywith the human protein. It has been suggested that AUH may have anovel role as a mitochondrial located AU-binding protein. Human AUHis expressed as a single mRNA species of 1.8 kb, and translated asa 40-kDa precursor protein which is subsequently processed to a32-kDa mature form.
Other Names:
Methylglutaconyl-CoA hydratase, mitochondrial, AU-specific RNA-binding enoyl-CoA hydratase, AU-binding protein/enoyl-CoA hydratase, AUH
Gene Name: AUH
Gene ID: 549
Primary Accession: Q13825
Other Accession: NP_001689.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The methylglutaconyl-CoA hydratase, mitochondrial proteinbinds to the AU-rich element (ARE), a common element found in the3' UTR of rapidly decaying mRNA such as c-fos, c-myc andgranulocyte/ macrophage colony stimulating factor. ARE elements areinvolved in directing RNA to rapid degradation and deadenylation.AUH is also homologous to enol-CoA hydratase, an enzyme involved infatty acid degradation, and has been shown to have intrinsichydratase enzymatic activity. AUH is thus a bifunctional chimerabetween RNA binding and metabolic enzyme activity. A possiblesubcellular localization in the mitochondria has been demonstratedfor the mouse homolog of this protein which shares 92% identitywith the human protein. It has been suggested that AUH may have anovel role as a mitochondrial located AU-binding protein. Human AUHis expressed as a single mRNA species of 1.8 kb, and translated asa 40-kDa precursor protein which is subsequently processed to a32-kDa mature form.
Other Names:
Methylglutaconyl-CoA hydratase, mitochondrial, AU-specific RNA-binding enoyl-CoA hydratase, AU-binding protein/enoyl-CoA hydratase, AUH
Gene Name: AUH
Gene ID: 549
Primary Accession: Q13825
Other Accession: NP_001689.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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