AURKAIP1 Polyclonal Antibody

Background:
AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Research Area: Cancer, Cell Biology

Synonyms:
28S ribosomal protein S38, AIP, AKIP, AURKA interacting protein, AURKA-interacting protein, AURKAIP 1, Aurkaip1, Aurora A kinase interacting protein, Aurora kinase A interacting protein 1, Aurora kinase A-interacting protein, FLJ20608, mitochondrial, MRP-S38

Immunogen: Recombinant protein of human AURKAIP1

Swissprot: Q9NWT8
Gene Accession: BC062333

Calculated MW: 22 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-70106/sc-70108