AXIN1 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP12033b
Background:
This gene encodes a cytoplasmic protein which contains aregulation of G-protein signaling (RGS) domain and a dishevelledand axin (DIX) domain. The encoded protein interacts withadenomatosis polyposis coli, catenin beta-1, glycogen synthasekinase 3 beta, protein phosphate 2, and itself. This proteinfunctions as a negative regulator of the wingless-type MMTVintegration site family, member 1 (WNT) signaling pathway and caninduce apoptosis. The crystal structure of a portion of thisprotein, alone and in a complex with other proteins, has beenresolved. Mutations in this gene have been associated withhepatocellular carcinoma, hepatoblastomas, ovarian endometriodadenocarcinomas, and medullablastomas. Two transcript variantsencoding distinct isoforms have been identified for this gene.
Other Names:
Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN
Gene Name: AXIN1
Gene ID: 8312
Primary Accession: O15169
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a cytoplasmic protein which contains aregulation of G-protein signaling (RGS) domain and a dishevelledand axin (DIX) domain. The encoded protein interacts withadenomatosis polyposis coli, catenin beta-1, glycogen synthasekinase 3 beta, protein phosphate 2, and itself. This proteinfunctions as a negative regulator of the wingless-type MMTVintegration site family, member 1 (WNT) signaling pathway and caninduce apoptosis. The crystal structure of a portion of thisprotein, alone and in a complex with other proteins, has beenresolved. Mutations in this gene have been associated withhepatocellular carcinoma, hepatoblastomas, ovarian endometriodadenocarcinomas, and medullablastomas. Two transcript variantsencoding distinct isoforms have been identified for this gene.
Other Names:
Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN
Gene Name: AXIN1
Gene ID: 8312
Primary Accession: O15169
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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