AXIN1 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP12033b
Catalog Number: AC-AP12033b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31751
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31751
Applications: IHC-P, WB
Datasheet
Request Information
Background:
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
Other Names:
Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN
Target/Specificity:
This AXIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 710-738 amino acids from the C-terminal region of human AXIN1.
Antigen Region:
710-738
Antigen Type: Synthetic Peptide
Gene Name: AXIN1
Gene ID: 8312
Primary Accession: O15169
NCBI Accession: NP_003493.1;NP_851393.1
Other Accession: NP_851393.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
Other Names:
Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN
Target/Specificity:
This AXIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 710-738 amino acids from the C-terminal region of human AXIN1.
Antigen Region:
710-738
Antigen Type: Synthetic Peptide
Gene Name: AXIN1
Gene ID: 8312
Primary Accession: O15169
NCBI Accession: NP_003493.1;NP_851393.1
Other Accession: NP_851393.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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