AXIN2 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP5416b
Background:
The Axin-related protein, Axin2, presumably plays animportant role in the regulation of the stability of beta-cateninin the Wnt signaling pathway, like its rodent homologs, mouseconductin/rat axil. In mouse, conductin organizes a multiproteincomplex of APC (adenomatous polyposis of the colon), beta-catenin,glycogen synthase kinase 3-beta, and conductin, which leads to thedegradation of beta-catenin. Apparently, the deregulation ofbeta-catenin is an important event in the genesis of a number ofmalignancies. The AXIN2 gene has been mapped to 17q23-q24, a regionthat shows frequent loss of heterozygosity in breast cancer,neuroblastoma, and other tumors. Mutations in this gene have beenassociated with colorectal cancer with defective mismatch repair.
Other Names:
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
The synthetic peptide sequence is selected from aa 831-843 of HUMAN AXIN2
Gene Name: AXIN2
Gene ID: 8313
Primary Accession: Q9Y2T1
Other Accession: O70240; O88566; NP_004646.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The Axin-related protein, Axin2, presumably plays animportant role in the regulation of the stability of beta-cateninin the Wnt signaling pathway, like its rodent homologs, mouseconductin/rat axil. In mouse, conductin organizes a multiproteincomplex of APC (adenomatous polyposis of the colon), beta-catenin,glycogen synthase kinase 3-beta, and conductin, which leads to thedegradation of beta-catenin. Apparently, the deregulation ofbeta-catenin is an important event in the genesis of a number ofmalignancies. The AXIN2 gene has been mapped to 17q23-q24, a regionthat shows frequent loss of heterozygosity in breast cancer,neuroblastoma, and other tumors. Mutations in this gene have beenassociated with colorectal cancer with defective mismatch repair.
Other Names:
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
The synthetic peptide sequence is selected from aa 831-843 of HUMAN AXIN2
Gene Name: AXIN2
Gene ID: 8313
Primary Accession: Q9Y2T1
Other Accession: O70240; O88566; NP_004646.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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