Axin2 polyclonal, anti-human, mouse, rat

Background:
b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.

Alternative Name:
Axil, AXIN2, Axil, Axin like protein, Axin-2, Axin-like protein, Axin2, AXIN2, Axis inhibition protein 2, Conductin, DKFZp781B0869, MGC10366, MGC126582,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:10-1:50

Specificity: Axin2 polyclonal antibody detects endogenous levels of Axin2 protein.

Immunogen:
recombinant protein

MW: 94 kDa

Swiss-Prot: Q9Y2T1(Human) O88566(Mouse) O70240(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.