AXIN2 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP5416b
Catalog Number: AC-AP5416b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB26798
Applications: WB, FC, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB26798
Applications: WB, FC, IHC-P
Datasheet
Request Information
Background:
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Other Names:
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
Antigen Region:
816-843
Antigen Type: Synthetic Peptide
Gene Name: AXIN2
Gene ID: 8313
Primary Accession: Q9Y2T1
NCBI Accession: NP_004646.3
Other Accession: O70240; O88566; NP_004646.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Other Names:
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity:
This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
Antigen Region:
816-843
Antigen Type: Synthetic Peptide
Gene Name: AXIN2
Gene ID: 8313
Primary Accession: Q9Y2T1
NCBI Accession: NP_004646.3
Other Accession: O70240; O88566; NP_004646.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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