β-Arrestin 1 (clone 1H4-F5-C11), anti-human, mouse, rat

Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,neurotransmitters, or sensory signals.Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors.Besides the central nervous system,it is expressed at high levels in peripheral blood leukocytes,and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.[provided by RefSeq,Jan 2011]

Synonyms: ARB1, ARR1

Cellular Location: Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Membrane Nucleus clathrin-coated pit pseudopodium

Immunogen:
Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.

Gene Symbol: β-Arrestin 1

Gene ID: 408

Swiss prot: P49407

Calculated MW: 50kDa

Recommended dilution:
WB 1:500

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.